Secretary of State for the Southern Department
From British Offices and Honours
| Name | Entered office | Left office | Party | Notes |
|---|---|---|---|---|
| Sir Edward Nicholas | 1 June 1660 | 20 October 1662 | ||
| The Lord Arlington from 1672, the Earl of Arlington | 20 October 1662 | 11 September 1674 | ||
| Henry Coventry | 11 September 1674 | 26 April 1680 | ||
| The Earl of Sunderland | 26 April 1680 | 2 February 1681 | Tory | |
| Sir Leoline Jenkins | 2 February 1681 | 14 April 1684 | Tory | |
| The Earl of Sunderland | 14 April 1684 | 28 October 1688 | Tory | |
| The Earl of Middleton | 28 October 1688 | 2 December 1688 | Tory | |
| The Earl of Shrewsbury | 14 February 1689 | 2 June 1690 | Whig | |
| The Earl of Nottingham | 2 June 1690 | November 1693 | Tory | |
| Sir John Trenchard | November 1693 | 27 April 1695 | Whig | |
| The Duke of Shrewsbury | 27 April 1695 | 12 December 1698 | Whig | |
| James Vernon | 12 December 1698 | 14 May 1699 | Whig | |
| The Earl of Jersey | 14 May 1699 | 27 June 1700 | Tory | |
| James Vernon | 27 June 1700 | 4 January 1702 | Whig | |
| The Earl of Manchester | 4 January 1702 | 1 May 1702 | Whig | |
| The Earl of Nottingham | 2 May 1702 | 22 April 1704 | Tory | |
| Sir Charles Hedges | 18 May 1704 | 3 December 1706 | Tory | |
| The Earl of Sunderland | 3 December 1706 | 13 June 1710 | Whig | |
| The Lord Darmouth from 1711, the Earl of Dartmouth | 15 June 1710 | 6 August 1713 | Tory | |
| The Viscount Bolingbroke | 17 August 1713 | 31 August 1714 | Tory | |
| James Stanhope | 27 September 1714 | 22 June 1716 | Whig | |
| Paul Methuen | 22 June 1716 | 10 April 1717 | Whig | |
| Joseph Addison | 12 April 1717 | 14 March 1718 | Whig | |
| James Craggs | 16 March 1718 | 16 February 1721 | Whig | |
| The Lord Carteret | 4 March 1721 | 31 March 1724 | Whig | |
| The Duke of Newcastle | 6 April 1724 | 12 February 1748 | Whig | |
| The Duke of Bedford | 12 February 1748 | 13 June 1751 | Whig | |
| The Earl of Holdernesse | 18 June 1751 | 23 March 1754 | Whig | |
| Sir Thomas Robinson | 23 March 1754 | October 1755 | Whig | |
| Henry Fox | 14 November 1755 | 13 November 1756 | Whig | |
| William Pitt | 4 December 1756 | 6 April 1757 | Whig | |
| The Earl of Holdernesse | 6 April 1757 | 27 June 1757 | Whig | |
| William Pitt | 27 June 1757 | 5 October 1761 | Whig | |
| The Earl of Egremont | 9 October 1761 | 21 August 1763 | Whig | |
| The Earl of Halifax | 9 September 1763 | 10 July 1765 | Whig | |
| Henry Seymour Conway | 12 July 1765 | 23 May 1766 | Whig | |
| The Duke of Richmond | 23 May 1766 | 29 July 1766 | Whig | |
| The Earl of Shelburne | 30 July 1766 | 20 October 1768 | Whig | |
| The Viscount Weymouth | 21 October 1768 | 12 December 1770 | Bedford Whig/Tory | |
| The Earl of Rochford | 19 December 1770 | 9 November 1775 | Tory | |
| The Viscount Weymouth | 9 November 1775 | 24 November 1779 | Tory | |
| The Earl of Hillsborough | 24 November 1779 | 27 March 1782 | Tory |
