| Name | Entered office | Left office | Party | Notes |
|---|---|---|---|---|
| Christopher Addison | 24 June 1919 | 1 April 1921 | Liberal | |
| Sir Alfred Mond | 1 April 1921 | 19 October 1922 | Liberal | |
| Sir Arthur Griffith Boscawen | 24 October 1922 | 7 March 1923 | Conservative | |
| Neville Chamberlain | 7 March 1923 | 27 August 1923 | Conservative | |
| Sir William Joynson-Hicks | 27 August 1923 | 22 January 1924 | Conservative | |
| John Wheatley | 22 January 1924 | 3 November 1924 | Labour | |
| Neville Chamberlain | 6 November 1924 | 4 June 1929 | Conservative | |
| Arthur Greenwood | 7 June 1929 | 24 August 1931 | Labour | |
| Neville Chamberlain | 25 August 1931 | 5 November 1931 | Conservative | |
| Sir Edward Young | 5 November 1931 | 7 June 1935 | Conservative | |
| Sir Kingsley Wood | 7 June 1935 | 16 May 1938 | Conservative | |
| Walter Elliot | 16 May 1938 | 10 May 1940 | Conservative | |
| Malcolm MacDonald | 13 May 1940 | 8 February 1941 | National Labour | |
| Ernest Brown | 8 February 1941 | 11 November 1943 | National Liberal | |
| Henry Willink | 11 November 1943 | 26 July 1945 | Conservative | |
| Aneurin Bevan | 3 August 1945 | 17 January 1951 | Labour | |
| Hilary Marquand | 17 January 1951 | 26 October 1951 | Labour | |
| Harry Crookshank | 30 October 1951 | 7 May 1952 | Conservative | |
| Iain Macleod | 7 May 1952 | 20 December 1955 | Conservative | |
| Robin Turton | 20 December 1955 | 16 January 1957 | Conservative | |
| Dennis Vosper | 16 January 1957 | 17 September 1957 | Conservative | |
| Derek Walker-Smith | 17 September 1957 | 27 July 1960 | Conservative | |
| Enoch Powell | 27 July 1960 | 20 October 1963 | Conservative | |
| Anthony Barber | 20 October 1963 | 16 October 1964 | Conservative | |
| Kenneth Robinson | 18 October 1964 | 1 November 1968 |
Merged with Minister of Social Security to create Secretary of State for Social Services